Discovering Elusive Small Genes

Small bowel malignancy: an elusive diagnosis.

Discovering genes for new medicines.

Most readers of this magazine are probably familiar with the idea of a gene as something that transmits inherited traits from one generation to the next. Less well appreciated is that malfunctioning genes are deeply involved in most diseases, not only inherited ones. Cancer, atherosclerosis, osteoporosis, arthritis and Alzheimer’s disease, for example, are all characterized by specific changes ...

Elusive Knowledge" Elusive Knowledge'

We know a lot. I know what food penguins eat. I know that phones used to ring, but nowadays squeal, when someone calls up. I know that Essendon won the 1993 Grand Final. I know that here is a hand, and here is another. We have all sorts of everyday knowledge, and we have it in abundance. To doubt that would be absurd. At any rate, to doubt it in any serious and lasting way would be absurd; and ...

Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer Therapy

With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set of tools to accurately predict signaling network and clinical outcomes. Herein,...

Elusive Origins of the Extra Genes in Aspergillus oryzae

The genome sequence of Aspergillus oryzae revealed unexpectedly that this species has approximately 20% more genes than its congeneric species A. nidulans and A. fumigatus. Where did these extra genes come from? Here, we evaluate several possible causes of the elevated gene number. Many gene families are expanded in A. oryzae relative to A. nidulans and A. fumigatus, but we find no evidence of ...